ACS Medicinal Chemistry Letters

美国化学学会的药物化学信件有兴趣收到手稿，讨论药物化学的各个方面。该杂志将发表涉及广泛主题的研究，包括化合物设计和优化、生物评价、药物传递、显像剂以及小分子和大分子生物活性分子的药理学。具体领域包括但不限于：先导生物活性分子与药物(小分子与生物制剂)的鉴定、合成与优化；药物发现背景下新分子实体的生物学特性；用于识别或分析生物活性分子、配体及其目标物等的计算、化学信息学和结构研究；新颖和改进的方法，包括放射生物化学，广泛应用于药物化学；合成和天然(植物和其他)来源的生物活性分子的发现技术；药物动力学/药效学研究，涉及潜在的药物处置和反应机制；药物遗传学和药物基因组学研究用于加强药物设计和将药物化学转化为临床；药物代谢机制与代谢酶基因表达调控；与药物化学领域相关的化学专利。

ACS Medicinal Chemistry Letters is interested in receiving manuscripts that discuss various aspects of medicinal chemistry. The journal will publish studies that pertain to a broad range of subject matter, including compound design and optimization, biological evaluation, drug delivery, imaging agents, and pharmacology of both small and large bioactive molecules. Specific areas include but are not limited to:Identification, synthesis, and optimization of lead biologically active molecules and drugs (small molecules and biologics)Biological characterization of new molecular entities in the context of drug discoveryComputational, cheminformatics, and structural studies for the identification or SAR analysis of bioactive molecules, ligands and their targets, etc.Novel and improved methodologies, including radiation biochemistry, with broad application to medicinal chemistryDiscovery technologies for biologically active molecules from both synthetic and natural (plant and other) sourcesPharmacokinetic/pharmacodynamic studies that address mechanisms underlying drug disposition and responsePharmacogenetic and pharmacogenomic studies used to enhance drug design and the translation of medicinal chemistry into the clinicMechanistic drug metabolism and regulation of metabolic enzyme gene expressionChemistry patents relevant to the medicinal chemistry field