TOXICOLOGICAL SCIENCES

毒理学发表的研究文章与评估人类或动物接触化学药物、天然产品或合成材料可能对健康造成的不利影响有着广泛的相关性。在毒理学的所有领域，无论是描述性的还是机械性的，以及解释性的或理论性的调查中都发表了手稿，阐明了单独或结合接触有毒物质的风险评估影响。研究可能涉及实验动物或人类实验对象，也可能侧重于体外方法或实验动物使用的替代方法。发表毒理研究的文章，这些毒理研究属于结构性生化或功能性研究，研究暴露代谢或物种的剂量路线对毒性反应的影响，统计或基于机制的风险评估方法。毒物学的新方法。主要研究章节原始文章短通讯研讨会摘要研讨会或圆桌总结评论评论领域包括生化毒物学药物动力学药物动力学生殖和发育毒物学致癌免疫毒物学神经毒物学肺毒物学实验动物安全评价风险评估的替代方法。

Toxicological Sciences publishes research articles that are broadly relevant to assessing the potential adverse health effects resulting from exposure of human or animals to chemicals drugs natural products or synthetic materials. Manuscripts are published in all areas of toxicology both descriptive and mechanistic as well as interpretive or theoretical investigations that elucidate the risk assessment implications of exposure to toxic agents alone or in combination. Studies may involve experimental animals or human subjects or they may focus on in vitro methods or alternatives to the use of experimental animals. Presenting Articles on Toxicologic studies which are structural biochemical or functional in nature Investigations of the effects of dose route of exposure metabolism or species on toxic responses Statistical or mechanism-based approaches to risk assessment. New methods in toxicology. Featured Sections Original research articles short communications Symposium summaries Workshop or Roundtable summaries Reviews Commentaries Research Areas Include Biochemical toxicology pharmacokinetics pharmacodynamics Reproductive and developmental toxicology carcinogenesis Immunotoxicology neurotoxicology pulmonary toxicology In vitro methods alternatives to experimental animals Safety evaluation risk assessment.