ORGANIC & BIOMOLECULAR CHEMISTRY

有机与生物分子化学（OBC）出版了有机化学的原始和高影响的研究和评论。我们欢迎在全合成、合成方法或物理和理论有机化学方面显示出新的或显著改进的方案或方法的研究，以及在化学生物学、催化、超分子和大分子C的有机化学或分子设计方面显示出显著进步的研究。化学、理论化学、机制物理有机化学、药物化学或天然产物。杂志上发表的文章应该报道在这一领域产生重大影响的新工作。常规工作和增量工作通常不适合在期刊上发表。关于我们范围的关键领域的更多细节如下。在所有情况下，作者都应该在他们的文章中清楚地说明为什么要进行研究。有机合成：我们欢迎在所有有机合成领域的重要研究，包括小有机分子和生物分子的研究，以及在没有生物数据的情况下报告纯合成工作的研究。总合成或多步骤合成应报告新的或改进的策略或方法，或更有效的途径到目标化合物。方法学研究应该显示出对已知方法的显著改进。将已知方法扩展到不同类别的化合物的研究通常是不合适的，除非该类别在范围上与先前报告的方法有显著不同。物理和理论有机化学：我们欢迎报告反应性、选择性、键合或结构的新模型或新计算方法的研究，并与后续实验的设计有关联。这一相关性应该在论文中得到明确的证明。从报告的理论工作的结果中得出的可测试预测的描述可能最清楚地证明了相关性；这些预测的测试可以包含在描述预测的同一篇论文中。仅仅复制实验数据的计算研究不适用于OBC。化学生物学：我们欢迎在化学生物学的化学方面报道新的或改进的方法的文章，包括化学工具的设计、开发和使用，碳水化合物、蛋白质和核酸等生物分子的化学研究，或蛋白质-蛋白质相互作用和表观遗传学等生物过程，以及化学方法，如成像和标记技术。超分子、大分子和有机材料：我们欢迎在超分子或大分子化合物或有机材料的分子设计中报告重要新工作的研究，无论是有机合成中的强组分还是具有新的有机结构特征。您可能希望考虑我们的材料期刊以外的文章这一范围。传感器：我们发表的文章描述了离子和/或分子的传感器，前提是：（a）它们解决了与实际相关的目标和情况；（b）它们代表了对以前方法的显著和可证明的改进。特别是，人工环境中物种的传感器（例如有机溶剂中的亲水离子）通常不可用于出版。药物化学：我们欢迎报道针对药物化学应用的重要合成或生物有机研究的研究。研究表明，常规合成和生物测试通常不适用于OBC。我们的姊妹期刊Medchemcomm更适合报道在核心药物化学学科的重要研究的文章。天然产物：我们欢迎报道新的和有趣的天然产物合成（见上文有机合成指南）或生物合成途径化学研究的文章。当所报告的化合物：1）具有新的结构类别，具有未报告的碳骨架、异常功能组或异常修改和/或2）表现出一种强有力或意想不到的生物活性或意想不到的作用机制。常规隔离研究不适用于OBC。

Organic & Biomolecular Chemistry (OBC) publishes original and high impact research and reviews in organic chemistry.We welcome research that shows new or significantly improved protocols or methodologies in total synthesis, synthetic methodology or physical and theoretical organic chemistry as well as research that shows a significant advance in the organic chemistry or molecular design aspects of chemical biology, catalysis, supramolecular and macromolecular chemistry, theoretical chemistry, mechanism-oriented physical organic chemistry, medicinal chemistry or natural products.Articles published in the journal should report new work which makes a highly-significant impact in the field. Routine and incremental work is generally not suitable for publication in the journal.More details about key areas of our scope are below. In all cases authors should include in their article clear rationale for why their research has been carried out.Organic synthesis: We welcome important research in all areas of organic synthesis, including studies on small organic molecules and biomolecules, and studies that report purely synthetic work without biological data. Total or multistep syntheses should report new or improved strategies or methods, or a more efficient route to the target compound. Methodology studies should show a significant improvement on known methods. Research that extends known methodology to a different class of compounds is generally not suitable, unless that class is significantly different in scope to previously reported methodology.Physical and theoretical organic chemistry: We welcome studies that report new models of reactivity, selectivity, bonding or structure, or new computational methods and have relevance for the design of subsequent experiments. That relevance should be clearly justified in the paper. Relevance is perhaps most clearly demonstrated by the description of testable predictions derived from the results of the reported theoretical work; the tests of these predictions could be contained in the same paper in which the predictions are described. Computational research that merely reproduces experimental data is not suitable for OBC.Chemical biology: We welcome articles that report new or improved methodologies in the chemical aspects of chemical biology, including design, development and use of chemical tools, chemical studies of biomolecules such as carbohydrates, proteins and nucleic acids or biological processes such as protein-protein interactions and epigenetics, and chemical methods such as imaging and labelling techniques.Supramolecular, macromolecular and organic materials: We welcome studies that report important new work in the molecular design of supramolecular or macromolecular compounds or organic materials either with a strong component in organic synthesis or with novel organic structural features. You may wish to consider our materials journals for articles outside this scope.Sensors: We publish articles describing sensors for ions and/or molecules provided that: (a) they address targets and situations of practical relevance; and (b) they represent significant and demonstrable improvements on previous methodology. In particular, sensors for species in artificial surroundings (for example, hydrophilic ions in organic solvents) will not typically be acceptable for publication.Medicinal chemistry: We welcome studies that report significant synthetic or bioorganic research that is directed towards medicinal chemistry applications. Studies that show routine syntheses accompanied by biological testing are generally not suitable for OBC. Our sister journal, MedChemComm, is more suitable for articles that report significant research in core medicinal chemistry disciplines.Natural products: We welcome articles that report new and interesting syntheses of natural products (see Organic Synthesis guidelines above) or chemical studies of biosynthetic pathways. Isolation or identification studies are welcome when the compound being reported:1) Has a novel structural class with unreported carbon skeleton, unusual functional groups or unusual modifications and/or2) Displays a potent or unexpected biological activity or an unexpected mechanism of action. Routine isolation studies are not suitable for OBC.