Nanotoxicology

该杂志邀请有关纳米结构材料与生物之间相互作用研究的贡献。这种相互作用被称为“干湿界面”。虽然以分子形式呈现给生物体的物质的毒理学特性受到经典毒理学的支持，但在存在毒理学机制（主要由表面化学决定）的情况下，似乎存在分子或原子聚集的大小范围。正是这个大小范围定义了这个日志的范围。尽管该杂志的大部分活动将涉及对与纳米尺度材料的生物相互作用的研究，但其范围不应就此结束，而应扩大到包括所有人造纳米结构材料，例如，包括活组织与假体表面之间的相互作用（例如，磨损能生产纳米颗粒）或“生态纳米毒理学”（即纳米材料在生物圈中的运动、与细菌、无脊椎动物和脊椎动物的相互作用）。本杂志范围内相互作用的性质包括纳米结构材料及其分解产物在人类、实验动物、环境和生物群中的流动性、持久性和毒性。通过使用活体外和活体内风险评估方法来评估和测量这种相互作用的技术发展是本杂志感兴趣的一个主要领域。这些包括在生物系统中纳米颗粒通过膜的传输机制。在颗粒毒性领域，杂志希望鼓励提交论文的具体领域包括：与粒径减小相关的毒性机制。这些研究包括有助于理解与基本生理机制的潜在相互作用，如离子转运、K通道和钙摄取。同样具有相关性的还有颗粒的催化表面性质与其毒性的相关性、纳米颗粒作为佐剂的重要性及其在免疫毒性中的相关性以及纳米结构表面自由基生成的重要性。该杂志特别关注通过涂层和其他方法将毒性降至最低的方法，例如纳米颗粒在治疗疾病中的医学和治疗用途。该杂志在其范围内，通过职业和人群研究以及对照临床研究的流行病学论文，包括纳米结构材料的危害证据。

The journal invites contributions addressing research into the interactions between nano-structured materials and living matter. This interaction has been dubbed the 'wet dry interface'. While the toxicological properties of substances presenting to organisms as molecules comes under aegis of classical toxicology, there appears to be size range of aggregations of molecules or atoms where there are toxicological mechanisms which are determined predominantly by surface chemistry. It is precisely that size range which defines the scope of this journal. Although much of the activity of the journal will involve investigations of the biological interactions with nano-scale materials, its scope should not be seen to end there but to extend to include all man-made nano-structured materials, for example including the interactions between living tissues and the surfaces of prostheses (e.g. wearing can produce nanoparticles) or in the context of 'eco-nanotoxicology' (i.e. the movement of nanomaterials through the biosphere, interactions with bacteria, invertebrates and vertebrates). The nature of the interactions within the scope of the journal includes the mobility, persistence and toxicity of nano-structured materials and their breakdown products in humans, experimental animals, the environment and within biota. Developments in technique for assessing and measuring such interactions through the use of in vitro and in vivo methods for risk assessments are a major area of interest for the journal. These include mechanisms of transport of nano-particles across membranes in living systems. Specific areas in the field of particle toxicity in which the journal wishes to encourage submission of papers include: the mechanism of toxicity associated with diminishing particle size. These include investigations leading to understanding of potential interactions with basic physiological mechanisms such as ion-transport, K-channels and Ca uptake. Also of relevance are the relevance of catalytic surface properties of particles to their toxicity, the importance of nano-particles as adjuvants and their relevance in immuno-toxicity and the significance of free radical generation at nano-structured surfaces. The journal is particularly interested in methods of toxicity minimisation, through coatings and other methods, in fields such as the medical and therapeutic use of nano-particles in the treatment of disease. The journal includes within its scope evidence of harm from nano-structured materials through epidemiological papers from occupational and population studies as well as controlled clinical studies