MECHANISMS OF AGEING AND DEVELOPMENT

《老化和发展机制》是一份多学科期刊，出版原创研究、理论和评论文章，旨在阐明包括人类在内的生物系统老化和发展过程的基本机制。欢迎所有与上述有关的基础研究领域的文章，但一般不接受那些描述年龄、发育和其他随时间而变化的文章，而不提及它们的起源或对其他结构和功能水平的影响。临床病例记录和报告的心理和社会影响的生物过程的老化不属于该杂志的范围。随着人类平均预期寿命的增加，老龄化和与年龄有关的疾病对我们社会的影响也在增加。老化研究现在是包括遗传学、分子和细胞生物学、生物化学和行为领域的领导者在内的数千个实验室的重点。老龄化研究综述(ARR)涵盖了这一领域的趋势。它的目的是填补一个很大的空白，即一个来源的批判性评论和观点的新发现的机制老化和年龄相关的疾病。在对控制细胞增殖、分化和存活机制的理解方面的快速进展，正导致对衰老调控的新见解。从端粒酶到干细胞，再到能量和氧自由基代谢，这是衰老研究领域的一个令人兴奋的新时代。正在确定延长寿命的操作的细胞和分子基础，例如热量限制，并正在开发预防与年龄有关的疾病的新方法。ARR出版的文章聚焦于从衰老研究的广泛领域中选择的主题，强调衰老过程的细胞和分子机制以及与年龄相关的疾病，如癌症、心血管疾病、糖尿病和神经退行性疾病。基础老化研究在延长寿命和预防疾病方面的应用也在本杂志中报道。

Mechanisms of Ageing and Development is a multidisciplinary journal for the publication of original research, theoretical and review articles, directed towards the illumination of the fundamental mechanisms underlying the process of ageing and development in biological systems, including man. Articles in all basic research areas relevant to the above are welcomed, but those describing age, developmental and other time-dependent changes without reference to their origins or effects on other levels of structure and function will not generally be accepted. Clinical case histories and reports on psychological and social influences on the biological processes of ageing do not fall within the scope of the journal. As the average human life expectancy has increased, so too has the impact of ageing and age-related disease on our society. Ageing research is now the focus of thousands of laboratories that include leaders in the areas of genetics, molecular and cellular biology, biochemistry, and behaviour. Ageing Research Reviews (ARR) covers the trends in this field. It is designed to fill a large void, namely, a source for critical reviews and viewpoints on emerging findings on mechanisms of ageing and age-related disease. Rapid advances in understanding of mechanisms that control cellular proliferation, differentiation and survival are leading to new insight into the regulation of ageing. From telomerase to stem cells to energy and oxyradical metabolism, this is an exciting new era in the multidisciplinary field of ageing research. The cellular and molecular underpinnings of manipulations that extend lifespan, such as caloric restriction, are being identified and novel approaches for preventing age-related diseases are being developed. ARR publishes articles on focussed topics selected from the broad field of ageing research, with an emphasis on cellular and molecular mechanisms of the ageing process and age-related diseases such as cancer, cardiovascular disease, diabetes and neurodegenerative disorders. Applications of basic ageing research to lifespan extension and disease prevention are also covered in this journal.