GENES CHROMOSOMES & CANCER

基因染色体与癌症将提供快速出版的原始全长研究文章，简短的沟通观点评论给编辑的信件，以及与肿瘤研究有关的基因分析的编辑评论。重点将放在结合分子和细胞遗传学分析癌症细胞基因组变化的工作上。尽管将优先采用分析方法进行研究，描述性研究和病例报告也将受到欢迎，特别是当它们提供关于肿瘤疾病基本生物学机制或临床管理的见解时。涵盖的具体领域包括：所有良性和恶性疾病的染色体异常，包括肿瘤进展期间发生的变化基因结构和调节的变化，由于基因组重排，涉及与细胞增殖和分化调节相关的基因的染色体改变。基因组异常与细胞表型改变之间的相关性：染色体和DNA水平变化对疾病预后的预测价值；设计和监测癌症治疗；细胞遗传学分子和流行病学分析易患癌症的遗传性疾病；染色体和/或遗传性疾病。由外部因素引起的MAGE描述了用于基因组分析的新的分子生物学和细胞遗传学方法。

Genes Chromosomes & Cancer will offer rapid publication of original full-length research articles brief communications perspectives reviews letters to the editors as well as editorial commentaries on genetic analysis as related to the study of neoplasia. Particular emphasis will be placed on work combining molecular and cytogenetic analyses of the genomic alterations of cancer cells. While preference will be given to research using analytical approaches descriptive studies and case reports will also be welcomed particularly when they offer insights regarding basic biologic mechanisms or the clinical management of neoplastic disorders. Specific areas covered will include: Chromosomal abnormalities in all benign and malignant disorders including changes that occur during neoplastic progression Changes in gene structure and regulation as a consequence of genomic rearrangements Chromosomal alterations involving genes related to the regulation of cell proliferation and differentiation The correlation between genomic abnormalities and cellular phenotypic alterations The predictive value of alterations at the chromosomal and DNA levels in disease prognosis and in designing and monitoring cancer therapies Cytogenetic molecular and epidemiologic analyses of inherited disorders predisposing to cancer Chromosomal and/or genetic damage caused by external factors Descriptions of novel molecular biological and cytogenetic methods for genomic analysis.