CLINICAL THERAPEUTICS

临床治疗学提供同行评审，快速公布药物和其他疗法的最新进展，以及药物经济学、健康政策、治疗结果以及药物和生物制剂研究的创新。此外，临床治疗的特点，更新的具体主题由专家专题编辑整理。在各种研究、学术和临床实践环境中，国际上大量的科学家和临床医师阅读临床治疗学。文章被所有主要的生物医学文摘数据库编入索引。已发表的文章范围从在大型多中心试验中探索新的化学实体的关键性研究到探索市场化试剂的再利用。此外，试点研究；评估所有开发阶段药物安全性和耐受性的报告；新的给药途径和新的制剂；药代动力学、生物可用性和生物相似性；以及实践指南和标准的变化，都是值得发表的。临床治疗学还了解通过发表复制研究、阴性试验和失败试验来加强特定药物周围证据的重要性。除了临床之外，我们还寻求研究治疗学的现实意义的报告，如比较有效性和药理学研究，以及对健康政策有影响的工作。评注，包括观点和当代问题，旨在提供一个平衡的观点和学术意见，广泛的毒品相关的主题。病例报告仍然是我们任务的重要组成部分，为临床提供了宝贵的经验教训。所有的手稿都由独立的临床医生或科学家进行同行评审，以确定临床相关性、技术准确性、方法严谨性、清晰度和客观性，并采用盲评过程。除了每月出版的专题文章外，每一期的临床治疗都有一个专门的主题部分，专门针对特定主题领域的年度更新。特邀编辑将包括每一个更新，包括评论、评论和原始研究，突出主题专业的新内容或有争议的内容。作者被邀请在主题更新中提交手稿以供考虑，并在其附信中确定提交内容。未选择用于更新的提交将被视为常规发布。2019主题更新日历在http://www.ees.elsevier.com/clinther提交您的手稿。

Clinical Therapeutics provides peer-reviewed, rapid publication of recent developments in drug and other therapies as well as in pharmacoeconomics, health policy, treatment outcomes, and innovations in drug and biologics research. In addition Clinical Therapeutics features updates on specific topics collated by expert Topic Editors. Clinical Therapeutics is read by a large international audience of scientists and clinicians in a variety of research, academic, and clinical practice settings. Articles are indexed by all major biomedical abstracting databases.Published articles range from pivotal studies exploring new chemical entities in large, multicenter trials to those exploring repurposing of marketed agents. Additionally, pilot studies; reports that assess drug safety and tolerability in all phases of development; new routes of administration and new formulations; pharmacokinetic, bio-availability, and biosimilarity; and changes in practice guidelines and standards, are all of interestfor publication. Clinical Therapeutics also understands the importance of strengthening the body of evidencesurrounding particular agents through the publication of replication studies, negative trials, and failed trials. Beyond the clinic, we seek reports that examine the real-world implications of therapeutics such as comparative effectiveness and pharmacoeconomics studies as well as work that has implications for health policy. Commentaries, which include perspectives and contemporary issues, are sought to offer a balance of viewpoints and scholarly opinion on a broad array of drug-related topics. Case reports, which remain a vital part of our mission, offer clinically valuable lessons. All manuscripts are peer reviewed by independent clinicians or scientists for clinical relevance, technical accuracy, methodological rigor, clarity, and objectivity using a blind review process.In addition to feature articles published monthly, each issue of Clinical Therapeutics features a specific theme section dedicated to an annual update of a specific topic area. A special guest editor will comprise each update with reviews, commentaries, and original research highlighting what's new or controversial in the topical specialty. Authors are invited to submit manuscripts for consideration in the topic updates, identifying submissions as such in their cover letters. Submissions not selected for the updates will be considered for general publication. 2019 TOPIC UPDATE CALENDAR Submit your manuscript at http://www.ees.elsevier.com/clinther